Active pharmaceutical ingredients (APIs) and platinum specialities for drugs

VUAB Pharma a.s. offers to its customers both APIs and platinum specialities for a production of anticancer drugs and toll manufacturing possibilities for APIs and HPAPIs. All products are produced under strict GMP conditions in a certified production unit.

Platinum specialities and platinum APIs for drugs 

• dipotassium tetrachloroplatinate, K₂PtCl₄, CAS [10025-99-7]

The product has the quality for drugs and it is a basic compound for preparing both platinum specialities and platinum drugs.

• potassium trichloroammineplatinate, K[PtCl₃(NH₃)],  CAS [13820-91-2]

The product has a quality for drugs and it is a basic intermediate for preparing of platinum complexes with different amino ligands, e.g. picoplatin, satraplatin, LA-12 and their analogues. The product is produced according to a patent protected procedure.

• (1R,2R)-1,2-diaminocyclohexane platinum(II) dichloride, CAS [52691-24-4]

The product has a quality for drugs and it is an intermediate for preparing oxaliplatin and its analogues.

• (1R,2R)-1,2-diaminocyclohexane platinum(II) diiodide, CAS [66845-32-7]

The product has a quality for drugs and it is an intermediate for preparing oxaliplatin and its analogues.

• oxaliplatin, API, CAS [61825-94-3]

The API is the anticancer drug with the quality according to the valid PhEur specification. GMP certificate and DMF are available, CEP application was filed. 

• oxaliplatin- standard impurity "B" according to PhEur specification, CAS [60732-70-9]

The product has a high quality and it is used as a standard for HPLC analysis according to the PhEur specification.

• oxaliplatin- standard impurity "C" according to PhEur specification, CAS [111321-67-6]

The product has a high quality and it is used as a standard for HPLC analysis according to the PhEur specification.

• oxaliplatin- standard impurity "D" according to PhEur specification, CAS [61758-77-8]

The product has a high chiral purity and it is used as a standard for HPLC analysis according to the PhEur specification.

Other APIs

• dacarbazin, API, CAS [4342-03-4]

The API is the anticancer drug with the quality according to the valid PhEur specification. GMP certificate is available. DMF and CEP are in the preparation. 

Development products

• picoplatin, API, CAS  [181630-15-9]

The compound has a high purity and it is prepared according to the original and non-infringing procedure. The samples are available. This compound is a new anticancer drug which is in the clinical trials by the originator nowadays. We recommend an infringement analysis in single territories before its commercial use.

APIs and HPAPIs toll manufacturing possibilities

VUAB Pharma a.s. has a certified production unit in Brno for a possible toll manufacturing of APIs and HPAPIs. There are available several independent production modules in the class "C" and "D" with the independent air conditions and qualified employees.